The pandemic exposed tons of human realities, one of them being ‘global supply chain,’ the epicentre of which lies at China, or East Asia essentially. It was in wake of this along with the lingering tensions between China and the USA over a variety of issues including trade that the calculations of supply changes started bothering everyone alike. India, and for that matter, South Asia, is best positioned to fill that vacuum and take the lead. Historically, South Asia played a calculated role in supply chains but with the turn of century things have changed. With new responsibilities and opportunities lying at the doorstep, India has all that it needs to take the leap forward. This also coincides with India’s great power ambitions, as its economy strengthens, so will its other sectors. India would need to grab this opportunity at the earliest with more smart business strategies, hurdle reduction, private-public collaboration, regional engagement, and outward oriented development strategies, because no great power could succeed without the supply chain lead.