Madhyamaka is not only a distinctive teaching that guides practitioners to liberation in the Northern Buddhist community, but also has the ability to be applied to modern social life. This paper examines the process of reception, transformation and application of Madhyamaka in Vietnam, from Nagarjuna’s interpretation and the Prajna literature to Buddhist practice in Vietnam (especially the Truc Lam Zen sect in the past and present). From a religious perspective, the paper approaches Madhyamaka as an interdependent system of wisdom – philosophy – cultural expression, implemented through three dimensions: cognition, practice and organization of life. The paper uses descriptive-analytical methods combining textual and field surveys. Research results show that Madhyamaka is currently being considered as a method to support psychological therapy, liberal education and the development of a culture of mindfulness in the world. In Vietnam, there are also opportunities and challenges in bringing Madhyamaka into monastery environments, lay communities, and modern society. Therefore, we can see Madhyamaka as a living wisdom heritage, which has the ability to accompany Vietnamese people to overcome existential and cultural crises in the era of transformation