The United States of America (USA) is not a new diplomatic actor in Africa. At the eve of independence of most African country, the USA played a very active role and its influence has grown remarkably, especially in the field of democracy and good governance. Cameroon’s diplomatic tie with the USA is characterised by visits, counter visits and mutual assistance within the political, socio-cultural and economic domains established and consolidated by the first head of state, President Ahmadou Ahidjo and the present government. The areas that continue to stir the USA and make Cameroon a more attractive destination include its raw material and numerous business opportunities. Other areas of concern which seek to boast this diplomatic tie include: health, security, education, trade and investment, rural development, culture and sport. These converging points have established a seemingly win-win diplomatic partnership between both countries, especially at the first signal. Based on the above, this paper re-examined Cameroon’s diplomatic relation with the USA from 1960 to 1990. It equally articulates Cameroon’s diplomatic stance within the framework of modernity, masterminded by the USA, in collaboration with other capitalists, socialists and communists’ relations around the world. Also, it looks at the principles and objectives of Cameroon’s diplomacy within this multifaceted context, piloted by globalisation. Finally, the analysis concluded that Cameroon significantly benefited both socially and economically in this diplomatic tie with the USA.